Methylamine → HCID 18613731, 화합물

HRID 705113노트

반응식

HRID 705113 반응식
Br[CH:2]([C:4]1[N:5]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:6](=[O:14])[C:7]2[CH:13]=[CH:12][CH:11]=[N:10][C:8]=2[N:9]=1)[CH3:3].[CH3:22][NH2:23]>C(O)C>[F:21][C:18]1[CH:19]=[CH:20][C:15]([N:5]2[C:6](=[O:14])[C:7]3[CH:13]=[CH:12][CH:11]=[N:10][C:8]=3[N:9]=[C:4]2[CH:2]([NH:23][CH3:22])[CH3:3])=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 18613734HCID 18613734, 화합물

생성물 1

HCID 18613731HCID 18613731, 화합물수율 83%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

A suspension of the bromide (18) (80 mg, 0.23 mmol) and 8.03M solution of methylamine in ethanol (0.64 mL) was heated to 40° C. for 3 h, and stirred at ambient temperature overnight. The resulting suspension was concentrated to dryness under reduced pressure, and the resulting light brown solid was taken up in dichloromethane and filtered through a silica-gel plug to give the title amine (19) (57 mg, 83%) as a beige solid (The crude material was directly taken through the next step without further purification).

후처리

  1. concentrationThe resulting suspension was concentrated to dryness under reduced pressure
  2. filtrationfiltered through a silica-gel plug

출처 및 근거

ORD 기록
ord-ca8adda3805844ec83a245536bc4ea4e
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09173869B2

반응 노트

불러오는 중…