4-Fluoropiperidine hydrochloride → HCID 178441820, 화합물

반응식

[CH2:1]([C:5]1[N:6]=[C:7]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=2)[C:8]2[NH:13][N:12]=[C:11]([C:14]#[C:15][CH2:16][CH2:17][CH2:18][CH2:19]Cl)[C:9]=2[N:10]=1)[CH2:2][CH2:3][CH3:4].Cl.[F:34][CH:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1>>[CH2:1]([C:5]1[N:6]=[C:7]([NH:21][CH2:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[C:25]([O:31][CH3:32])[CH:24]=2)[C:8]2[NH:13][N:12]=[C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:38]3[CH2:39][CH2:40][CH:35]([F:34])[CH2:36][CH2:37]3)[C:9]=2[N:10]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

반응물 2

HCID 27591584-Fluoropiperidine hydrochloride

HCID 178441818HCID 178441818, 화합물

생성물 1

HCID 178441820HCID 178441820, 화합물

실험 절차

Prepared similarly to Intermediate 24 from 5-butyl-3-(6-chlorohex-1-yn-1-yl)-N-(3,4-dimethoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine and 4-fluoropiperidine hydrochloride

출처 및 근거

ORD 기록: ord-3018a24a07b043fbb403c1b3c0e7a398
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09173872B2

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