참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Silane, tris(1-methylethyl)- | HCID 138754 | — |
| 반응물 | 6-Iodo-2-methoxy-3-[(4-methoxybenzyl)oxy]pyridine | HCID 86658006 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | HCID 58452305 | HCID 58452305 | 96% |
반응 단계
Triisopropylsilane (2.1 g) and trifluoroacetic acid (4.0 mL) were added to a solution of 6-iodo-2-methoxy-3-[(4-methoxybenzyl)oxy]pyridine (1 g) in chloroform (10 mL), and the mixture was stirred at 0° C. for one hour. The solvent was evaporated from the reaction solution under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:10→50:50) to give the title compound as a colorless powder (604 mg, 96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08822503B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-183bad4a36804068b6fe87ce50790428 |
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| 출처 메모 | uspto-grants-2014_09 |
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