Thionyl Chloride → 5-Chloro-2-iodobenzoyl chloride
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].O=S(Cl)[Cl:14]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
To a solution of 5-chloro-2-iodobenzoic acid (3.0 g, 10.6 mmol) in toluene (150 mL), SOCl2 (7.75 mL, 106 mmol) was added and the mixture was heated at 100° C. for 3 hours. The solvent was concentrated in vacuum and the residue was co-evaporated from toluene twice to give the title compound as a grey solid. Yield (3.2 g, 100%)
후처리
- concentrationThe solvent was concentrated in vacuum
출처 및 근거
- ORD 기록
- ord-1c8449d22bf54d2cabf83b2c45026c65
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09174977B2
반응 노트
불러오는 중…