Water → 4-Bromo-2-chloro-1-(ethylsulfanyl)benzene
반응식
[CH2:1]([S-:3])[CH3:2].[Na+].[Br:5][C:6]1[CH:11]=[CH:10][C:9](F)=[C:8]([Cl:13])[CH:7]=1.O>CN(C)C=O>[Br:5][C:6]1[CH:11]=[CH:10][C:9]([S:3][CH2:1][CH3:2])=[C:8]([Cl:13])[CH:7]=1참가 물질
5
반응 조건
- 온도
- 65 °C
실험 절차
Sodium ethanethiolate (2.0 g) was added to a solution of 4-bromo-2-chloro-1-fluorobenzene (5.0 g) in N,N-dimethylformamide (20 mL), and the mixture was stirred at 65° C. for two hours. The reaction solution was poured into water, followed by extraction with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and filtered. The solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:1→0:100) to give the title compound as a colorless oil (4.8 g).
후처리
- extractionfollowed by extraction with ethyl acetate
- washThe organic layer was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- customThe solvent was then evaporated under reduced pressure
- customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:1→0:100)
출처 및 근거
- ORD 기록
- ord-a2e05521131d48fa887d2bc0d813faf0
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822503B2
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