Potassium Carbonate → 4-{[6-(Trifluoromethyl)-3-pyridinyl]oxy}benzaldehyde

HRID 705890노트

반응식

HRID 705890 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[N:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.F[C:13]1[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[F:11][C:2]([F:1])([F:10])[C:3]1[N:8]=[CH:7][C:6]([O:9][C:13]2[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][CH:14]=2)=[CH:5][CH:4]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 680234-FluorobenzaldehydeHCID 27833885-Hydroxy-2-(trifluoromethyl)pyridine

생성물 1

HCID 866662084-{[6-(Trifluoromethyl)-3-pyridinyl]oxy}benzaldehyde수율 100%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
130 °C

실험 절차

To a solution of 6-(trifluoromethyl)-3-pyridinol (2 g, 12.26 mmol) and 4-fluorobenzaldehyde (1.315 ml, 12.26 mmol) in DMF (50 mL), was added K2CO3 (2.54 g, 18.39 mmol). The mixture was heated at 130° C. overnight. After cooling, the reaction mixture was diluted in water, extracted with EA. The organic phase was washed with water and brine, dried over Na2SO4, concentrated to afford the title compound (3.28 g, 12.26 mmol, 100% yield) as a brown oil. LCMS: rt=3.16 min, [M+H+]=268

후처리

  1. temperatureAfter cooling
  2. extractionextracted with EA
  3. washThe organic phase was washed with water and brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-930b557daadf434db2568173861b0085
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174968B2

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