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Potassium Carbonate → HCID 178494126, 화합물

HRID 706005
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HRID 706005 반응식
F[C:2]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]2[NH:13][CH:14]=[C:15]([CH2:19][C:20]3[CH:21]=[N:22][C:23]([O:26][CH3:27])=[N:24][CH:25]=3)[C:16](=[O:18])[N:17]=2)=[CH:6][C:3]=1[C:4]#[N:5].[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([OH:35])=[CH:31][C:30]=1[C:36]([F:39])([F:38])[F:37].C([O-])([O-])=O.[K+].[K+]>CN1C(=O)CCC1>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][C:2]2[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]3[NH:13][CH:14]=[C:15]([CH2:19][C:20]4[CH:21]=[N:22][C:23]([O:26][CH3:27])=[N:24][CH:25]=4)[C:16](=[O:18])[N:17]=3)=[CH:6][C:3]=2[C:4]#[N:5])=[CH:31][C:30]=1[C:36]([F:37])([F:38])[F:39]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 805204-Chloro-3-(trifluoromethyl)phenolHCID 1784941232-Fluoro-5-(2-(5-((2-methoxypyrimidin-5-yl)methyl)-4-oxo-1,4-dihydropyrimidin-2-yl)ethyl)benzonitrile

생성물 1

HCID 178494126HCID 178494126, 화합물수율 25.3%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

To a solution of 2-fluoro-5-[2-(5-{[2-(methyloxy)-5-pyrimidinyl]methyl}-4-oxo-1,4-dihydro-2-pyrimidinyl)ethyl]benzonitrile (80 mg, 0.219 mmol) and 4-chloro-3-(trifluoromethyl)phenol (64.6 mg, 0.328 mmol) in NMP (2 mL), K2CO3 (60.5 mg, 0.438 mmol) was added. The reaction vessel was sealed and stirred at room temp for 10 min, and heated by microwave to 150° C. for 2 h. Purification via MDAP then afforded the title compound as a white solid (30 mg, 25.3% yield). LCMS: rt=3.19 min, [M+H+]=542

후처리

  1. customThe reaction vessel was sealed
  2. temperatureheated by microwave to 150° C. for 2 h
  3. customPurification via MDAP

출처 및 근거

ORD 기록
ord-3bfb212dbdfd475998ef0c76d30bcb49
출처 데이터셋
uspto-grants-2015_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09174968B2

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