참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-(Cyclohexen-1-yl)aniline | HCID 6709749 | — |
| 반응물 | 4-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester | HCID 22507380 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-[3-(cyclohexen-1-yl)phenyl]-4-hydroxy-3-methoxyphenylacetamide | HCID 22019669 | 86% |
반응 단계
4-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester (60 mg) and Intermediate 2 (60 mg) are dissolved in ethyl acetate, and the mixture is stirred at 60° C. for 18 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the title compound (50 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07084176B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-cd1c80ce4ddb43ffb41ba233536d3992 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
