Trifluoroacetic acid → HCID 89524905, 화합물

HRID 706349노트

반응식

HRID 706349 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[O:8]1[CH:12]=[C:11]([C:13]2[CH:27]=[CH:26][CH:25]=[CH:24][C:14]=2[CH2:15][NH:16]C(=O)OC(C)(C)C)[N:10]=[CH:9]1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[O:8]1[CH:12]=[C:11]([C:13]2[CH:27]=[CH:26][CH:25]=[CH:24][C:14]=2[CH2:15][NH2:16])[N:10]=[CH:9]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 89524967HCID 89524967, 화합물

생성물 1

HCID 89524905HCID 89524905, 화합물수율 142.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Added trifluoroacetic acid (5 mL, 64.9 mmol) to a solution of tert-butyl 2-(oxazol-4-yl)benzylcarbamate (200 mg, 0.729 mmol) in Dichloromethane (DCM) (5 mL) and let stir at room temperature for 1 hour. Concentrated to dryness. Obtained 300 mg of (2-(oxazol-4-yl)phenyl)methanamine trifluoroacetate. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.88-4.50 (m, 2H) 7.38-7.60 (m, 4H) 8.00 (s, 1H) 8.10 (s, 1H) 8.19-8.56 (m, 2H). MS[MH]+=175.1

후처리

  1. concentrationConcentrated to dryness

출처 및 근거

ORD 기록
ord-86f7468efdbb469a9826260ecc2fff07
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174984B2

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