Ethyl 6-(prop-1-en-2-yl)picolinate → Ethyl 6-isopropylpicolinate

HRID 706533노트

반응식

HRID 706533 반응식
[CH2:1]=[C:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)[CH3:3]>CCO.[Pd]>[CH:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:1]

참가 물질

4

반응물 1

HCID 67974687Ethyl 6-(prop-1-en-2-yl)picolinate

생성물 1

HCID 67974663Ethyl 6-isopropylpicolinate수율 93.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To ethyl 6-(prop-1-en-2-yl)picolinate (4.63 g, 24.2 mmol) in EtOH (50 mL) was added Pd/C (0.61 g, 0.573 mmol). The reaction mixture was purged with nitrogen three times and then with hydrogen three times. A hydrogen balloon was applied to the reaction for three hours. The reaction was then purged with N2, filtered through Celite and washed with EtOH (100 mL). Solvent was removed under reduced pressure to give 4.36 g (93%) of ethyl 6-isopropylpicolinate.

후처리

  1. customThe reaction mixture was purged with nitrogen three times
  2. customA hydrogen balloon was applied to the reaction for three hours
  3. customThe reaction was then purged with N2
  4. filtrationfiltered through Celite
  5. washwashed with EtOH (100 mL)
  6. customSolvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-885d3dc645b0449cbbfffc6d85500b27
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174981B2

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