Thionyl Chloride → 3-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride

HRID 706589노트

반응식

HRID 706589 반응식
[CH:1]([N:4]1[CH:8]=[CH:7][C:6]([CH2:9]O)=[N:5]1)([CH3:3])[CH3:2].O=S(Cl)[Cl:13]>ClCCl>[ClH:13].[Cl:13][CH2:9][C:6]1[CH:7]=[CH:8][N:4]([CH:1]([CH3:3])[CH3:2])[N:5]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 23005538(1-(propan-2-yl)-1H-pyrazol-3-yl)methanol

생성물 1

HCID 672599053-(chloromethyl)-1-isopropyl-1H-pyrazole hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(1-Isopropyl-1H-pyrazol-3-yl)methanol was dissolved into dichloromethane and SOCl2 (2 equivalents) was added. The resulting mixture was allowed to stir overnight, then concentrated under vacuum to yield the desired compound (quantitative yield).

후처리

  1. additionwas added
  2. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-10872e3fca3641fa9c11700198ecd3cd
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174981B2

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