Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 7067생성일: 2026년 10월 25일
Triethylamine → 4-Hydroxy-3-methoxy-n-[3-[2-(2-trifluoromethylphenyl)ethynyl]phenyl]phenylacetamide
https://huagongshe.com/reaction/7067
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzene, 1-iodo-2-(trifluoromethyl)- | HCID 67957 | — |
| 반응물 | N-(3-ethynylphenyl)-4-hydroxy-3-methoxyphenyacetamide | HCID 86760178 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178419050 | HCID 178419050 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-Hydroxy-3-methoxy-n-[3-[2-(2-trifluoromethylphenyl)ethynyl]phenyl]phenylacetamide | HCID 12096663 | — |
반응 단계
A mixture of N-(3-ethynylphenyl)-4-hydroxy-3-methoxypheny-acetamide (the compound of Example 19) (200 mg), 1-trifluoromethyl-2-iodobenzene (280 mg), copper (I) iodide (19 mg), bis(triphenylphosphine)palladium (II) dichloride (70 mg), triethylamine (1 g) and acetonitrile (3 ml) is heated with stirring at 50° C. under argon atmosphere for 18 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the desired compound (120 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07084176B2 |
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| 출처 데이터셋 | uspto-grants-2006_08 |
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| ORD ID | ord-b5a3ba4d153e4ab996f6b3ba98b5134c |
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| 출처 메모 | uspto-grants-2006_08 |
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