Ethyl 6-(prop-1-en-2-yl)picolinate → Ethyl 6-isopropylpicolinate

HRID 706723노트

반응식

HRID 706723 반응식
[CH2:1]=[C:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)[CH3:3]>CCO.[Pd]>[CH:2]([C:4]1[N:9]=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=[CH:6][CH:5]=1)([CH3:3])[CH3:1]

참가 물질

4

반응물 1

HCID 67974687Ethyl 6-(prop-1-en-2-yl)picolinate

생성물 1

HCID 67974663Ethyl 6-isopropylpicolinate수율 93%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To ethyl 6-(prop-1-en-2-yl)picolinate (4.63 g, 24.2 mmol) in EtOH (50 mL) was added Pd/C (0.61 g, 0.573 mmol). The reaction mixture was purged with nitrogen and hydrogen three times each. A hydrogen balloon was applied to the reaction for three hours. The reaction was then purged with nitrogen, filtered through Celite® and washed with EtOH (100 mL). Solvent was removed under reduced pressure to give the desired product (93%).

후처리

  1. customThe reaction mixture was purged with nitrogen and hydrogen three times each
  2. customA hydrogen balloon was applied to the reaction for three hours
  3. customThe reaction was then purged with nitrogen
  4. filtrationfiltered through Celite®
  5. washwashed with EtOH (100 mL)
  6. customSolvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-a60ecab01f16470b85fe20fcb765939a
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174981B2

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