Aluminium lithium hydride → [5-methyl-1-(propan-2-yl)-1H-pyrazol-3-yl]methanol

HRID 706730

반응식

HRID 706730 반응식
[CH:1]([N:4]1[C:8]([CH3:9])=[CH:7][C:6]([C:10](OCC)=[O:11])=[N:5]1)([CH3:3])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH:1]([N:4]1[C:8]([CH3:9])=[CH:7][C:6]([CH2:10][OH:11])=[N:5]1)([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 23005696Ethyl 1-isopropyl-5-methyl-1H-pyrazole-3-carboxylate

생성물 1

HCID 23005569[5-methyl-1-(propan-2-yl)-1H-pyrazol-3-yl]methanol수율 88%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To ethyl 1-isopropyl-5-methyl-1H-pyrazole-3-carboxylate (7.68 g, 39.1 mmol) in THF (50 mL) at 0° C. was added LAH (1.49 g, 39.1 mmol). The cold bath was removed, and the reaction mixture was stirred for 2 hours and quenched carefully with sodium sulfate decahydrate. The reaction mixture was filtered through Celite® and washed with Et2O (200 mL). The filtrate was concentrated under reduced pressure to give the desired product (88%).

후처리

  1. customThe cold bath was removed
  2. customquenched carefully with sodium sulfate decahydrate
  3. filtrationThe reaction mixture was filtered through Celite®
  4. washwashed with Et2O (200 mL)
  5. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-758113da38c74d1793bc578a7b844a2a
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174981B2

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