Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 706886노트

반응식

HRID 706886 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

생성물 1

HCID 31128494-Morpholinobut-2-YN-1-OL

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
85 °C

실험 절차

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the pure title compound.

후처리

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-a4e3f6ea8f03421d80b5432a65bb7814
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174982B2

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