Sodium Carbonate → 3-nitro-N-(1-(quinolin-2-yl)azetidin-3-yl)pyridin-2-amine

HRID 707343노트

반응식

HRID 707343 반응식
Cl.[N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:15][CH:14]([NH2:16])[CH2:13]1.C(=O)([O-])[O-].[Na+].[Na+].Cl[C:24]1[C:29]([N+:30]([O-:32])=[O:31])=[CH:28][CH:27]=[CH:26][N:25]=1>CN(C)C=O.O>[N+:30]([C:29]1[C:24]([NH:16][CH:14]2[CH2:13][N:12]([C:3]3[CH:4]=[CH:5][C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[N:2]=3)[CH2:15]2)=[N:25][CH:26]=[CH:27][CH:28]=1)([O-:32])=[O:31]

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 796132-Chloro-3-nitropyridineHCID 67477378HCID 67477378, 화합물

생성물 1

HCID 866942023-nitro-N-(1-(quinolin-2-yl)azetidin-3-yl)pyridin-2-amine수율 85%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

To a solution of 1-(quinolin-2-yl)azetidin-3-amine hydrochloride (0.90 g, 3.84 mmol) in dry dimethylformamide (15 mL) was added sodium carbonate (1.22 g, 11.5 mmol) and 2-chloro-3-nitro-pyridine (608 mg, 3.84 mmol). The reaction mixture was stirred and heated at reflux for 14 hours. The reaction mixture was diluted with water (25 mL) and extracted with ethyl acetate (2×30 mL). The combined organic extracts were washed with water (30 mL), brine (30 mL), and dried over sodium sulfate. The filtrate was evaporated in vacuo and the residue was purified by column chromatography on silica gel (20% to 50% ethyl acetate in petroleum ether) to give 3-nitro-N-(1-(quinolin-2-yl)azetidin-3-yl)pyridin-2-amine (1.05 g, 3.20 mmol, 85% yield) as yellow solid.

후처리

  1. temperatureheated
  2. temperatureat reflux for 14 hours
  3. extractionextracted with ethyl acetate (2×30 mL)
  4. washThe combined organic extracts were washed with water (30 mL), brine (30 mL)
  5. dry with materialdried over sodium sulfate
  6. customThe filtrate was evaporated in vacuo
  7. customthe residue was purified by column chromatography on silica gel (20% to 50% ethyl acetate in petroleum ether)

출처 및 근거

ORD 기록
ord-06a561d50d1f4eaa86b271f8937d63e6
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09174992B2

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