3-(benzylamino)-N-methoxy-N-methylcyclobutanecarboxamide → 3-amino-N-methoxy-N-methylcyclobutanecarboxamide
반응식
C([NH:8][CH:9]1[CH2:12][CH:11]([C:13]([N:15]([O:17][CH3:18])[CH3:16])=[O:14])[CH2:10]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[NH2:8][CH:9]1[CH2:12][CH:11]([C:13]([N:15]([O:17][CH3:18])[CH3:16])=[O:14])[CH2:10]1참가 물질
4
실험 절차
A mixture of 3-(benzylamino)-N-methoxy-N-methylcyclobutanecarboxamide (349 mg, 2.2 mmol) and wet palladium hydroxide on activated carbon (50 wt %, 200 mg) in methanol (30 mL) was stirred under hydrogen (30 psi) at room temperature for 13 hours then the reaction mixture was filtered through CELITE™ H and washed with methanol. The filtrate was concentrated in vacuo to give 3-amino-N-methoxy-N-methylcyclobutanecarboxamide (332 mg, 2.09 mmol, yield 95%).
후처리
- filtrationthe reaction mixture was filtered through CELITE™ H
- washwashed with methanol
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-84ee059200d14a1abd932bf47428ff73
- 출처 데이터셋
- uspto-grants-2015_11
- 특허 번호
- US09174992B2
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