Diethyl 2,2-dihexylmalonate → 2,2-Dihexylpropane-1,3-diol

HRID 70754노트

반응식

HRID 70754 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].C([O:9][C:10](=O)[C:11]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[C:12](OCC)=[O:13])C>C1COCC1>[CH2:23]([C:11]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH2:10][OH:9])[CH2:12][OH:13])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

참가 물질

4

반응물 2

HCID 599758Diethyl 2,2-dihexylmalonateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 227192912,2-Dihexylpropane-1,3-diol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A suspension of lithium aluminum hydride (LAH) (2 g, 52.6 mmol) in dry THF (20 mL) was stirred at room temperature, and a THF solution of substituted malonic acid diethyl ester (26.3 mmol, (5)) was added dropwise. The reaction was allowed to reflux for 3 h and was quenched by the addition of cold water. The compound was extracted in ethyl acetate. The organic layer was washed with water, dried over Na2SO4, and evaporated to produce the product (6) as either a sticky liquid or a low-melting solid.

후처리

  1. temperatureto reflux for 3 h
  2. customwas quenched by the addition of cold water
  3. extractionThe compound was extracted in ethyl acetate
  4. washThe organic layer was washed with water
  5. dry with materialdried over Na2SO4
  6. customevaporated

출처 및 근거

ORD 기록
ord-64fc795d7941443292bd453da98fec03
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822635B2

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