1-Ethynyl-4-methoxybenzene → 5-(4-Methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

HRID 707627노트

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HRID 707627 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][CH:4]=1)#[CH:2].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([N:23]=[N+:24]=[N-:25])[CH:16]=[C:17]([O:21][CH3:22])[C:18]=1[O:19][CH3:20]>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([N:23]2[C:1]([C:3]3[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][CH:4]=3)=[CH:2][N:25]=[N:24]2)[CH:16]=[C:17]([O:21][CH3:22])[C:18]=1[O:19][CH3:20]

참가 물질

3

반응물 2

HCID 2510201-Ethynyl-4-methoxybenzeneHCID 59430102HCID 59430102, 화합물

생성물 1

HCID 445852705-(4-Methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole

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온도
80 °C

실험 절차

To a scintillation vial was added 4-ethynyl anisole (660 mg.; 5 mmol) and 3,4,5-trimethoxyphenyl azide (1.05 g.; 5 mmol) and the mixture was heated at 80° C. for 24 hours. The crude mixture was purified by column chromatography to give 1-(3,4,5-trimethoxy-phenyl)-5-(4-methoxy-phenyl)-1H-[1,2,3]triazole.

후처리

  1. customThe crude mixture was purified by column chromatography

출처 및 근거

ORD 기록
ord-fc400c0b3c7b4d198ae81546e95b4320
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09175022B2

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