4-Ethynyl-N,N-dimethylaniline → HCID 15603447, 화합물

HRID 707628노트

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HRID 707628 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=1)#[CH:2].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:24]=[N+:25]=[N-:26])[CH:17]=[C:18]([O:22][CH3:23])[C:19]=1[O:20][CH3:21]>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([N:24]2[C:1]([C:3]3[CH:8]=[CH:7][C:6]([N:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=3)=[CH:2][N:26]=[N:25]2)[CH:17]=[C:18]([O:22][CH3:23])[C:19]=1[O:20][CH3:21]

참가 물질

3

반응물 2

HCID 51918844-Ethynyl-N,N-dimethylanilineHCID 59430102HCID 59430102, 화합물

생성물 1

HCID 15603447HCID 15603447, 화합물

반응 조건

온도
80 °C

실험 절차

To a scintillation vial was added (4-ethynyl phenyl)-dimethyl amine (660 5 mmol) and 3,4,5-trimethoxyphenyl azide (1.05 g.; 5 mmol) and the mixture was heated at 80° C. for 24 hours. The crude mixture was purified by column chromatography to give 1-(3,4,5-trimethoxy-phenyl)-5-[4-(N,N-dimethylamino)-phenyl]-1H-[1,2,3]triazole.

후처리

  1. customThe crude mixture was purified by column chromatography

출처 및 근거

ORD 기록
ord-d54f30ffd7b8499aa29cfb361dc6b9bf
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09175022B2

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