N-chlorosuccinamide → Pyridine-2-carboximidoyl chloride

HRID 707640노트

반응식

HRID 707640 반응식
C([C:3]1[C:4]([CH:9]=[N:10]O)=[N:5][CH:6]=[CH:7][CH:8]=1)C.[Cl:12]NC(=O)CCC(N)=O>CN(C=O)C>[N:5]1[CH:6]=[CH:7][CH:8]=[CH:3][C:4]=1[C:9]([Cl:12])=[NH:10]

참가 물질

4

반응물 2

HCID 15238416N-chlorosuccinamideHCID 136338061Ethyl 2-pyridin-aldoxime

생성물 1

HCID 23228227Pyridine-2-carboximidoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
30 °C

실험 절차

To a mixture of ethyl 2-pyridin-aldoxime (15 gm) and N-chlorosuccinamide (25 gm) in DMF (30 ml) was stirred at 30° C. over a period of 2 h. The reaction mixture was quenched with ice-cold water (150 ml). The suspension was filtered and the wet cake washed with small quantity of water to provide pure title compound in 7 gm quantity (55%) as a white solid.

후처리

  1. customThe reaction mixture was quenched with ice-cold water (150 ml)
  2. filtrationThe suspension was filtered
  3. washthe wet cake washed with small quantity of water

출처 및 근거

ORD 기록
ord-b8551bfae5ee4eb1a2fb451ddede6637
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09175031B2

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