Pyridine 2-aldoxime → Pyridine-2-carboximidoyl chloride

HRID 707652노트

반응식

HRID 707652 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[N:8]O.[Cl:10]NC(=O)CCC(N)=O>CN(C=O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:10])=[NH:8]

참가 물질

4

반응물 2

HCID 13395Pyridine 2-aldoximeHCID 15238416N-chlorosuccinamide

생성물 1

HCID 23228227Pyridine-2-carboximidoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
30 °C

실험 절차

To a mixture of pyridin-2-carbaldehyde-oxime (15 gm) and N-chlorosuccinamide (25 gm) in DMF (30 ml) was stirred at 30° C. over a period of 2 h. The reaction mixture was quenched with ice cold water (150 ml). The suspension was filtered and the wet cake washed with small quantity of water to provide pure title compound in 7 gm quantity (55%) as a white solid.

후처리

  1. customThe reaction mixture was quenched with ice cold water (150 ml)
  2. filtrationThe suspension was filtered
  3. washthe wet cake washed with small quantity of water

출처 및 근거

ORD 기록
ord-139f8a6b12f24b56a6b32ee87fd3d9da
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09175031B2

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