Diethyl Ether → Picolinohydrazide

HRID 707657

반응식

HRID 707657 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([O:9]CC)=O.[NH2:12][NH2:13].C(OCC)C>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([NH:12][NH2:13])=[O:9]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 9321HydrazineHCID 17307Ethyl 2-pyridinecarboxylate

생성물 1

HCID 255881Picolinohydrazide

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of ethyl pyridin-2-carboxylate (90 gm) and hydrazine (60 gm) in ethanol (400 ml) was stirred at 80° C. over a period of 4 h. Solvent was evaporated and to provide a crude mass. The mass was stirred with diethyl ether and the suspension was filtered and the wet cake washed with small quantity of ethanol (50 ml) to provide title compound in 76 gm quantity (93%) as a white solid.

후처리

  1. customSolvent was evaporated
  2. customto provide a crude mass
  3. filtrationthe suspension was filtered
  4. washthe wet cake washed with small quantity of ethanol (50 ml)

출처 및 근거

ORD 기록
ord-d650448a01824a70a2ecd839870847ed
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09175031B2

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