4-hydroxy-N-(3-iodophenyl)-3-methoxyphenylacetamide → 4-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]-phenylacetamide

반응식

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14](I)[CH:13]=2)=[O:10])=[CH:4][C:3]=1[O:19][CH3:20].O[C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](NC2C=CC=CC=2I)=O)=[CH:24][C:23]=1OC>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:29]#[C:28][C:25]2[CH:26]=[CH:27][CH:22]=[CH:23][CH:24]=2)=[O:10])=[CH:4][C:3]=1[O:19][CH3:20]

참가 물질

반응물 2

HCID 120966604-hydroxy-N-(3-iodophenyl)-3-methoxyphenylacetamide

HCID 220196134-hydroxy-N-(2-iodophenyl)-3-methoxyphenylacetamide

생성물 1

HCID 220196734-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]-phenylacetamide

실험 절차

Instead of Intermediate 1 in Example 36, 4-hydroxy-N-(2-iodophenyl)-3-methoxyphenylacetamide is treated in a similar manner to Example 36 to give the desired compound.

출처 및 근거

ORD 기록: ord-89b0d7fa5702421e85b242cc98976b63
출처 데이터셋: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07084176B2

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