4-hydroxy-3-methoxy-N-[3-(2-phenylethynyl)phenyl]-phenylacetamide → 4-hydroxy-3-methoxy-N-[2-[(Z)-2-phenylvinyl]phenyl]-phenylacetamide

HRID 7079

반응식

HRID 7079 반응식
OC1C=CC(CC(NC2C=CC=C(C#CC3C=CC=CC=3)C=2)=O)=CC=1OC.[OH:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][C:36]([NH:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[C:45]#[C:46][C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)=[O:37])=[CH:31][C:30]=1[O:53][CH3:54]>>[OH:28][C:29]1[CH:34]=[CH:33][C:32]([CH2:35][C:36]([NH:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2/[CH:45]=[CH:46]\[C:47]2[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=2)=[O:37])=[CH:31][C:30]=1[O:53][CH3:54]

참가 물질

3

반응물 2

HCID 220196124-hydroxy-3-methoxy-N-[3-(2-phenylethynyl)phenyl]-phenylacetamide2회HCID 220196734-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]-phenylacetamide2회

생성물 1

HCID 586798704-hydroxy-3-methoxy-N-[2-[(Z)-2-phenylvinyl]phenyl]-phenylacetamide

실험 절차

Instead of 4-hydroxy-3-methoxy-N-[3-(2-phenylethynyl)phenyl]-phenylacetamide (the compound of Example 36) in Example 56, 4-hydroxy-3-methoxy-N-[2-(2-phenylethynyl)phenyl]phenylacetamide (the compound of Example 107) is treated in a similar manner to Example 56 to give the desired compound.

출처 및 근거

ORD 기록
ord-87e6898308db4b26a4226ae53366324d
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084176B2

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