HCID 67050596, 화합물 → HCID 58204143, 화합물
반응식
Br[C:2]1[CH:24]=[CH:23][C:5]2[C:6]3[N:7]=[C:8]([C:14]4[N:18]([CH:19]([CH3:21])[CH3:20])[N:17]=[C:16]([NH2:22])[N:15]=4)[S:9][C:10]=3[CH2:11][CH2:12][O:13][C:4]=2[CH:3]=1.[CH3:25][C:26]1([CH2:30][N:31]2[CH:35]=[C:34](B3OC(C)(C)C(C)(C)O3)[CH:33]=[N:32]2)[CH2:29][O:28][CH2:27]1>>[CH:19]([N:18]1[C:14]([C:8]2[S:9][C:10]3[CH2:11][CH2:12][O:13][C:4]4[CH:3]=[C:2]([C:34]5[CH:33]=[N:32][N:31]([CH2:30][C:26]6([CH3:25])[CH2:27][O:28][CH2:29]6)[CH:35]=5)[CH:24]=[CH:23][C:5]=4[C:6]=3[N:7]=2)=[N:15][C:16]([NH2:22])=[N:17]1)([CH3:21])[CH3:20]참가 물질
3
실험 절차
Similar to as described in General Procedure C, 5-(8-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-1-isopropyl-1H-[1,2,4]triazol-3-ylamine was reacted with 1-((3-methyloxetan-3-yl)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Purification of the crude reaction mixture by reverse phase HPLC gave 400. LCMS: 478.2
후처리
- customPurification of the crude
- customreaction mixture by reverse phase HPLC
출처 및 근거
- ORD 기록
- ord-daa3c07ccdae4ad0b53d8d664ca7df94
- 출처 데이터셋
- uspto-grants-2015_11