Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (R)-ethyl 3-amino-4-(biphenyl-4-yl)butanoate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | (R)-ethyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate | HCID 59607632 | — |
| 생성물 | (R)-ethyl 3-amino-4-(biphenyl-4-yl)butanoate hydrochloride | HCID 68424075 | — |
반응 단계
To (R)-ethyl-4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate (300 mg, 0.782 mmol) is added a solution of 4M HCl in 1,4-dioxane (3.92 mL, 15.65 mmol) at room temperature. After stirring for 1 hour, the reaction mixture is concentrated under reduced pressure to give (R)-3-amino-4-biphenyl-4-yl-butyric acid ethyl ester hydrochloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822534B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-7d89e934912440ea8d7b2adecce273ca |
| 출처 메모 | uspto-grants-2014_09 |