Hydrochloric Acid → (R)-ethyl 3-amino-4-(biphenyl-4-yl)butanoate hydrochloride

HRID 70827

반응식

HRID 70827 반응식
[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C@H:6]([NH:20]C(OC(C)(C)C)=O)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)[CH3:2].[ClH:29].O1CCOCC1>>[ClH:29].[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C@H:6]([NH2:20])[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:12][CH:13]=1)[CH3:2]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59607632(R)-ethyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate

생성물 1

HCID 68424075(R)-ethyl 3-amino-4-(biphenyl-4-yl)butanoate hydrochloride

실험 절차

To (R)-ethyl-4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate (300 mg, 0.782 mmol) is added a solution of 4M HCl in 1,4-dioxane (3.92 mL, 15.65 mmol) at room temperature. After stirring for 1 hour, the reaction mixture is concentrated under reduced pressure to give (R)-3-amino-4-biphenyl-4-yl-butyric acid ethyl ester hydrochloride.

후처리

  1. concentrationthe reaction mixture is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7d89e934912440ea8d7b2adecce273ca
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822534B2

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