Chlorotrimethylsilane → HCID 178452187, 화합물

HRID 708270노트

반응식

HRID 708270 반응식
[Zn:1].Cl[Si](C)(C)C.BrCCBr.[I:11][CH:12]1[CH2:15][N:14]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:13]1>CN(C)C(=O)C>[I-:11].[C:19]([O:18][C:16]([N:14]1[CH2:15][CH:12]([Zn+:1])[CH2:13]1)=[O:17])([CH3:22])([CH3:21])[CH3:20]

참가 물질

6

반응물 4

HCID 6397ChlorotrimethylsilaneHCID 78391,2-DibromoethaneHCID 23994ZincHCID 11000522Tert-butyl 3-iodoazetidine-1-carboxylate

생성물 1

HCID 178452187HCID 178452187, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매2회

실험 절차

Zinc (2.472 g, 0.03780 mol) was stirred in 10 mL of degassed N,N-dimethylacetamide under N2 atmosphere. Chlorotrimethylsilane (0.411 mL, 0.00324 mol) and 1,2-Dibromoethane (0.233 mL, 0.00270 mol) were added and the mixture was stirred for 20 minutes. Tert-butyl 3-iodoazetidine-1-carboxylate (7.644 g, 0.02700 mol) in degassed N,N-dimethylacetamide (60.0 mL) was added slowly and the cloudy reaction was stirred at room temperature for 1.5 hours to give (1-(tert-butoxycarbonyl)azetidin-3-yl)zinc(II) iodide.

후처리

  1. customthe cloudy reaction
  2. stirringwas stirred at room temperature for 1.5 hours

출처 및 근거

ORD 기록
ord-3379675bb8cf46e78f328747ff03c638
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09175009B2

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