Thionyl Chloride → 3-(Biphenyl-4-yl)propanoyl chloride

HRID 70871

반응식

HRID 70871 반응식
[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][C:9](O)=[O:10])=[CH:3][CH:2]=1.O=S(Cl)[Cl:20]>>[C:1]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][C:9]([Cl:20])=[O:10])=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 30824342(4-Biphenyl)propionic acid

생성물 1

HCID 596075633-(Biphenyl-4-yl)propanoyl chloride수율 101%

반응 조건

온도
85 °C

실험 절차

A mixture of 3-(4-biphenylyl)propionic acid (5 g, 22.10 mmol) and SOCl2 (4.03 ml, 55.2 mmol) is refluxed under nitrogen at 85° C. for 1.5 hour. The reaction mixture is concentrated under reduced pressure to give 3-(biphenyl-4-yl)propanoyl chloride (5.46 g). The material is used in the next step without further purification.

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7a907a9b5dd44db180e5b9d82e7bc00b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822534B2

연결된 노트

불러오는 중…