Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetic Acid → 2-(chloromethyl)-4-methoxy-1H-benzo[d]imidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetic Acid | HCID 300 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 6-Nitro-o-anisidine | HCID 85491 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(chloromethyl)-4-methoxy-1H-benzo[d]imidazole | HCID 22018753 | 86.6% |
반응 단계
A solution of 2-amino-3-methoxy-1-nitrobenzene (0.860 g, 5.11 mmol) in MeOH (50 mL) was hydrogenated (1 atm) over palladium, 10 wt. % on activated carbon (0.163 g). The resultant crude 3-methoxy-1,2-phenylenediamine was reacted with chloroacetic acid (0.953 g, 10.08 mmol) in refluxing 4 N HCl (10 mL) overnight. After aqueous workup, 0.87 g of 2-chloromethyl-4-methoxy-1H-benzimidazole was isolated as a red-brown solid, which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084155B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-24bc86431bd542409b1544b66fd7149e |
| 출처 메모 | uspto-grants-2006_08 |