Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 708976생성일: 2026년 10월 24일
Cesium carbonate → 1-[(6-Chloro-3-pyridyl)methyl]-3-(4-cyanophenyl)-4-oxo-pyrido[1,2-a]pyrimidin-1-ium-2-olate
https://huagongshe.com/ko/reaction/708976
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| 반응물 | 1-[(6-Chloro-3-pyridyl)methyl]-3-iodo-4-oxo-pyrido[1,2-a]pyrimidin-1-ium-2-olate | HCID 86709267 | — |
| 촉매 | HCID 178479802 | HCID 178479802 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 1-[(6-Chloro-3-pyridyl)methyl]-3-(4-cyanophenyl)-4-oxo-pyrido[1,2-a]pyrimidin-1-ium-2-olate | HCID 86709265 | — |
반응 단계
To a mixture of 53 mg (0.36 mmol) (4-cyanophenyl)boronic acid, 100 mg (0.24 mmol) 1-[(6-chloro-3-pyridyl)methyl]-3-iodo-4-oxo-pyrido[1,2-a]pyrimidin-1-ium-2-olate (Synthesis described in WO 2009/099929), 35 mg (0.05 mmol) bis(triphenylphosphino)-palladium dichloride and 17 mg (0.05 mmol) caesium carbonate was added 160 ml of dioxane. The mixture was heated to 100° C. for 18 hours. Silica was added and the product was obtained by column chromatographie (dichloromethane/methanol) (24 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09179680B2 |
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| 출처 데이터셋 | uspto-grants-2015_11 |
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| ORD ID | ord-715d6f14d2c14ccca7073c53661c3515 |
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| 출처 메모 | uspto-grants-2015_11 |
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