Benzonatate → Benzonatate calcium silicate
반응식
[Si:1]([O-:5])([O-:4])([O-:3])[O-:2].[Ca+2:6].[Ca+2].[CH3:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:14]=[CH:15][C:16]([C:19]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][O:45][CH2:46][CH2:47][O:48][CH3:49])=[O:20])=[CH:17][CH:18]=1>>[CH3:8][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][O:39][CH2:40][CH2:41][O:42][CH2:43][CH2:44][O:45][CH2:46][CH2:47][O:48][CH3:49])=[O:20])=[CH:15][CH:14]=1.[Si:1]([O-:5])([O-:4])([O-:3])[O-:2].[Ca+2:6].[Ca+2:6]참가 물질
3
실험 절차
Using the ingredients and amounts in the preceding table, calcium silicate was mixed at slow speed in a high shear granulator (Impeller: 250 rpm and Chopper: 3200 rpm). The liquid benzonatate was added to this mixture at slow speed (Impeller: 250 rpm and Chopper: 3200 rpm) at a rate of approximately 7 g/minute. The resulting benzonatate-calcium silicate adsorbate granules formed were passed through a 425 micron screen.
후처리
- additionwas mixed at slow speed in a high shear granulator (Impeller: 250 rpm and Chopper: 3200 rpm)
출처 및 근거
- ORD 기록
- ord-9710e590ab294e5890569f37735168f7