3-Chloro-5-fluorobenzyl Bromide → 5-[(3-Chloro-5-fluorobenzyl)sulfanyl]-2,3-dimethoxypyridine

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[CH2:5][S:6][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[C:10]([O:13][CH3:14])=[N:11][CH:12]=1.BrCC1C=C([F:28])C=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[C:18]([F:28])[CH:19]=1)[CH2:5][S:6][C:7]1[CH:8]=[C:9]([O:15][CH3:16])[C:10]([O:13][CH3:14])=[N:11][CH:12]=1

참가 물질

반응물 2

HCID 27348343-Chloro-5-fluorobenzyl Bromide

HCID 711858335-(3-Chlorobenzylthio)-2,3-dimethoxypyridine2회

생성물 1

HCID 711862245-[(3-Chloro-5-fluorobenzyl)sulfanyl]-2,3-dimethoxypyridine

실험 절차

Prepared as described for 5-(3-chlorobenzylthio)-2,3-dimethoxypyridine (Intermediate 8) but using 1-(bromomethyl)-3-chloro-5-fluorobenzene instead of 1-(bromomethyl)-3-chlorobenzene.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-26524f4fbb604da6b9247a6fd1753a0a
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09180122B2

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