Potassium cyanate → 1-[1-(2-Chlorophenyl)-2-nitroethyl]urea

HRID 709138노트

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HRID 709138 반응식
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([NH2:14])[CH2:10][N+:11]([O-:13])=[O:12].[O-:15][C:16]#[N:17].[K+]>O.CO>[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([NH:14][C:16]([NH2:17])=[O:15])[CH2:10][N+:11]([O-:13])=[O:12]

참가 물질

4

반응물 2

HCID 11378442Potassium cyanateHCID 866947771-(2-Chlorophenyl)-2-nitroethanamine hydrochloride

생성물 1

HCID 680324091-[1-(2-Chlorophenyl)-2-nitroethyl]urea

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

반응 조건

온도
40 °C

실험 절차

At RT, 300 mg (about 93% pure, 1.18 mmol) of the compound of Example 25A were initially charged in 12 ml of water/methanol (1:1 v/v), and 287 mg (3.53 mmol) of potassium cyanate were added. The reaction mixture was warmed to 40° C. for 1 h. After cooling to RT, the mixture was directly separated into its components by preparative HPLC [Method 8]. This gave 120 mg (41% of theory) of the title compound.

후처리

  1. temperatureAfter cooling to RT
  2. customthe mixture was directly separated into its components by preparative HPLC [Method 8]

출처 및 근거

ORD 기록
ord-96a4bc65a8ce4fffb7c64e0a35592eb5
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09180120B2

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