Methanesulfonyl chloride → HCID 56848687, 화합물

반응식

Cl.[NH2:2][CH:3]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]([F:34])([F:33])[F:32])[CH2:4][NH:5][C:6](=[O:24])[CH2:7][N:8]1[C:12](=[O:13])[N:11]([CH2:14][CH2:15][O:16][CH3:17])[C:10]([C:18]2[S:19][C:20]([Cl:23])=[CH:21][CH:22]=2)=[N:9]1.[CH3:35][S:36](Cl)(=[O:38])=[O:37]>>[Cl:23][C:20]1[S:19][C:18]([C:10]2[N:11]([CH2:14][CH2:15][O:16][CH3:17])[C:12](=[O:13])[N:8]([CH2:7][C:6]([NH:5][CH2:4][CH:3]([NH:2][S:36]([CH3:35])(=[O:38])=[O:37])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([F:32])([F:33])[F:34])=[O:24])[N:9]=2)=[CH:22][CH:21]=1

참가 물질

반응물 2

HCID 31297Methanesulfonyl chloride

HCID 89764091HCID 89764091, 화합물

생성물 1

HCID 56848687HCID 56848687, 화합물

실험 절차

Analogously to the procedure of Example 68, 29 mg (46 μmol) of the compound of Example 60A were reacted with methanesulphonyl chloride. This gave 25 mg (92% of theory) of the title compound.

출처 및 근거

ORD 기록: ord-d49192dd9046487bb72479e4bba8301b
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09180120B2

반응 노트

불러오는 중…