Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene, 1-bromo-3-nitro- → 2-Bromo-6-nitroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene, 1-bromo-3-nitro- | HCID 11457 | — |
| 반응물 | O-methylhydroxylammonium chloride | HCID 11639 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 촉매 | Cuprous chloride | HCID 62652 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Bromo-6-nitroaniline | HCID 11469989 | 6% |
반응 단계
A mixture of 3-bromonitrobenzene (6.06 g, 30 mmol) and o-methylhydroxylamine hydrochloride (3.13 g, 37.5 mmol) were reacted in the presence of copper (I) chloride (0.59 g, 6 mmol) and potassium t-butoxide (10.1 g, 90 mmol) in DMF (75 mL). Aqueous work-up and chromatography gave 2-amino-3-bromonitrobenzene (0.36 g, 6%) as an orange powder. 1H NMR (CDCl3) δ 6.60 (t, 1H, J=9 Hz), 7.70 (d, 1H, J=9 Hz), 8.14 (d, 1H, J=9 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084155B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-5da6dc30a40e4b98a9086a0a634513ee |
| 출처 메모 | uspto-grants-2006_08 |