Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-Phenylenediamine → 2-(2-Chloroethyl)benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-Phenylenediamine | HCID 7243 | — |
| 반응물 | 3-Chloropropionic acid | HCID 7899 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 2-(2-Chloroethyl)benzimidazole | HCID 12216288 | 32.3% |
반응 단계
A mixture of 1,2-Phenylenediamine (1.3 g, 12.0 mmol) and 3-chloropropionic acid (2.0 g, 18.5 mmol) were refluxed in 4N HCl (13 mL) for 16 hours to give the title compound as white solid (700 mg, 32%). 1H NMR (CD3OD) □ 3.35 (t, 2H, J=6.8 Hz), 4.00 (t, 2H, J=6.8 Hz), 7.18–7.25 (m, 2H), 7.49–7.55 (m, 2H); ES-MS m/z 181.0 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084155B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-708aa2cb8cff44d5bab91807ea9877e3 |
| 출처 메모 | uspto-grants-2006_08 |