Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-Phenylenediamine → 2-Benzimidazolepropanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-Phenylenediamine | HCID 7243 | — |
| 반응물 | 4-Chlorobutanoic acid | HCID 12300 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 2-Benzimidazolepropanol | HCID 75470 | 50% |
반응 단계
A mixture of 1,2-Phenylenediamine (1.0 g, 12.0 mmol) and 4-chlorobutyric acid (1.5 mL, 15.17 mmol) were refluxed in 4N HCl (13 mL) for 16 hours under N2 to give the title compound as white solid (900 mg, 50%). 1H NMR (CD3OD) □ 2.04–2.08 (m, 2H), 2.97 (t, 2H, J=7.8 Hz), 5.64 (t, 2H, J=6.6 Hz), 7.15–7.21 (m, 2H), 7.47–7.49 (m, 2H); ES-MS m/z 177.1 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084155B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-e9d7394b8fab4a7884fe9288c6c7895d |
| 출처 메모 | uspto-grants-2006_08 |