Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1258784-67-6
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | tert-Butyl(trans)-2-[4-(benzyloxy)phenyl]cyclopropylcarbamate | HCID 15480693 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 1258784-67-6 | HCID 66715085 | 87% |
반응 단계
HCl in Dioxane (390 ml) was added to a solution of tert-butyl ((trans)-2-(4-(benzyloxy)phenyl)cyclopropyl)carbamate (Intermediate U, 78 g, 0.23 mol) in 1,4-dioxane (780 mL) at 0° C. and stirred at RT for 12 h. After completion, the solvent was evaporated and the residue was triturated with diethyl ether (1 L) followed by hexane (1 L) to give (trans)-2-(4-(benzyloxy)phenyl)cyclopropanamine hydrochloride (55 g, 87%) as off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181198B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-3a5fe46482114071b07b88612e421bc5 |
| 출처 메모 | uspto-grants-2015_11 |