Ethyl 3-(3-(benzyloxy)-4-methylphenyl)acrylate → Ethyl 3-(3-hydroxy-4-methylphenyl)propanoate

HRID 709661노트

반응식

HRID 709661 반응식
C([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:12]=[CH:13][C:14]=1[CH3:15])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:12]=[CH:13][C:14]=1[CH3:15]

참가 물질

4

반응물 1

HCID 131733900Ethyl 3-(3-(benzyloxy)-4-methylphenyl)acrylate

생성물 1

HCID 117759964Ethyl 3-(3-hydroxy-4-methylphenyl)propanoate수율 85.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of ethyl 3-(3-(benzyloxy)-4-methylphenyl)acrylate (2.50 g) in ethanol (50 mL) was added 10% palladium-activated carbon (250 mg) and, under a hydrogen atmosphere, the mixture was stirred at room temperature for 15 hr. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.50 g) as a colorless oil.

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-fe54c0b0165c40e18d6f230120a55172
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181186B2

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