Sodium hydride → 4-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

참여 물질

역할	이름	HCID	투입량
반응물	Sodium hydride	HCID 24758	—
반응물	2-Chloromethyl 2-(trimethylsilyl)ethyl ether	HCID 2724271	—
반응물	HCID 178418822	HCID 178418822	—
생성물	4-phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole	HCID 22018576	67%

반응 단계

Reaction of 4-phenylimidazole (400 mg, 2.78 mmol), NaH (60%, 108 mg, 2.70 mmol), and SEMCl (520 uL/2.94 mmol) followed by column chromatography on silica gel (hexane/EtOAC 1:1) gave the title compound (500 mg, 67%) as a yellow oil. 1H NMR (300 MHz, CDCl3) δ 0.00 (s, 9H), 0.92 (t, 2H, J=9.0 Hz), 3.54 (t, 2H, J=9.0 Hz), 5.27 (s, 2H), 7.17 (s, 1H), 7.37–7.47 (m, 3H), 7.56 (d, 2H, J=9.0 Hz), 7.68 (s, 1H). ES-MS m/z 275 (M+H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07084155B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-5367d4f1fa96453a9bf752f5ac239e8c
출처 메모	uspto-grants-2006_08