Toluene → Ethyl (2-fluoro-3-methoxyphenyl)acrylate

HRID 709717

반응식

HRID 709717 반응식
[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.C1(P(=C[C:32]([O:34][CH2:35][CH3:36])=[O:33])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:37]1(C)C=CC=CC=1>>[F:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4](=[CH2:37])[C:32]([O:34][CH2:35][CH3:36])=[O:33]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 37744632-Fluoro-3-methoxybenzaldehyde

생성물 1

HCID 131733905Ethyl (2-fluoro-3-methoxyphenyl)acrylate

반응 조건

온도
110 °C

실험 절차

To a solution of 2-fluoro-3-methoxybenzaldehyde (2.00 g) in toluene (50 mL) was added ethyl (triphenylphosphoranylidene)acetate (4.50 g), and the mixture was stirred at 110° C. for 4 hr. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (2.50 g) as a colorless oil.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-ec62c66f8bda401e941f3729936ef69c
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181186B2

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