Water → (3-Methoxy-5-methylphenyl)methanol

HRID 709721

반응식

HRID 709721 반응식
Br[CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([O:10][CH3:11])[CH:4]=1.C(=O)([O-])[OH:13].[Na+].O>CC(C)=O>[CH3:11][O:10][C:5]1[CH:4]=[C:3]([CH2:2][OH:13])[CH:8]=[C:7]([CH3:9])[CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 5855341-(Bromomethyl)-3-methoxy-5-methylbenzene

생성물 1

HCID 11030016(3-Methoxy-5-methylphenyl)methanol수율 80.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1-(bromomethyl)-3-methoxy-5-methylbenzene (2.14 g) in acetone (80 mL) were added sodium hydrogen carbonate (1.05 g) and water (50 mL), and the mixture was heated under reflux for 18 hr. The reaction mixture was extracted with ethyl acetate, and the extract was washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.22 g) as a yellow oil.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 18 hr
  3. extractionThe reaction mixture was extracted with ethyl acetate
  4. washthe extract was washed with saturated brine
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was evaporated under reduced pressure
  7. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-cb45ff73b9a34a3c921d4b4483304c8b
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181186B2

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