2-Ethylaniline → 5,7-Dichloro-3-methyl-1H-indazole

HRID 70974

반응식

HRID 70974 반응식
[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:3]=1[NH2:4].C(C1C([NH2:20])=CC=CC=1)C.ClN1C(=O)CCC1=O>C(#N)C>[Cl:9][C:7]1[CH:6]=[C:5]2[C:3](=[C:2]([Cl:1])[CH:8]=1)[NH:4][N:20]=[C:10]2[CH3:11]

참가 물질

5

반응물 3

HCID 113572-EthylanilineHCID 31398ChlorosuccinimideHCID 118198342,4-Dichloro-6-ethylaniline

생성물 1

HCID 1784343295,7-Dichloro-3-methyl-1H-indazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

5,7-Dichloro-3-methyl-1H-indazole was prepared using a procedure similar to that described in Example 98, part a and b, except starting from 2,4-dichloro-6-ethylaniline (2.9 g) that was prepared by chlorination of 6-ethylaniline (10 g) with N-chlorosuccinimide (22 g) in acetonitrile (80 mL).

출처 및 근거

ORD 기록
ord-9fbb7237748140b7a07313f7f1f64687
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822689B2

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