Sodium hydride → 5-(4-Nitrophenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

참여 물질

역할	이름	HCID	투입량
반응물	Sodium hydride	HCID 24758	—
반응물	2-Chloromethyl 2-(trimethylsilyl)ethyl ether	HCID 2724271	—
반응물	HCID 178418805	HCID 178418805	—
생성물	5-(4-Nitrophenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole	HCID 22018541	65%

반응 단계

Reaction of 4-(4-nitrophenyl)-1H-imidazole (160 mg, 0.85 mmol), NaH (60%, 33 mg, 0.82 mmol), and SEMCl (158 uL, 0.89 mmol) followed by column chromatography on silica gel (hexane/EtOAC 3:2) gave the title compound (170 mg, 65%) as a yellow solid. 1H NMR (300 MHz, CDCl3) δ 0.00 (s, 9H), 0.94 (t, 2H, J=7.5 Hz), 3.55 (t, 2H, J=7.5 Hz), 5.33 (s, 2H), 7.50 (s, 1H), 7.69 (s, 1H), 7.94 (d, 2H, J=6.0 Hz), 8.26 (d, 2H, J=6.0 Hz).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07084155B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-f76d24e594c14444b92e85c37f612993
출처 메모	uspto-grants-2006_08