Trifluoroacetic acid → N-((R)-1-(4-Fluorophenyl)-2-hydroxyethyl)-4-((S)-morpholin-2-yl)benzamide

HRID 710257노트

반응식

HRID 710257 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([C@@H:20]3[O:25][CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]3)=[CH:16][CH:15]=2)=[O:13])[CH2:9][OH:10])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:11][C:12](=[O:13])[C:14]2[CH:19]=[CH:18][C:17]([C@@H:20]3[O:25][CH2:24][CH2:23][NH:22][CH2:21]3)=[CH:16][CH:15]=2)[CH2:9][OH:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 89689438HCID 89689438, 화합물

생성물 1

HCID 89689472N-((R)-1-(4-Fluorophenyl)-2-hydroxyethyl)-4-((S)-morpholin-2-yl)benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(S)-tert-butyl 2-(4-((R)-1-(4-fluorophenyl)-2-hydroxyethylcarbamoyl)phenyl)morpholine-4-carboxylate (44 mg, 0.099 mmol) was dissolved in dichloromethane (0.3 ml) and trifluoracetic acid (447 mg, 0.3 ml, 3.92 mmol) was added. The reaction mixture was stirred at room temperature for 60 min. The solvent and excess of trifluoracetic acid were evaporated. The residue was dissolved in dichloromethane (3 ml) and extracted with odium bicarbonate saturated solution (2 ml). The organic layer was dried over MgSO4 and evaporated. The crude product was directly used for the next step.

후처리

  1. customThe solvent and excess of trifluoracetic acid were evaporated
  2. dissolutionThe residue was dissolved in dichloromethane (3 ml)
  3. extractionextracted with odium bicarbonate saturated solution (2 ml)
  4. dry with materialThe organic layer was dried over MgSO4
  5. customevaporated

출처 및 근거

ORD 기록
ord-8e991b8a49ac4ae1b636bb15359c4856
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181230B2

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