Cesium carbonate → tert-Butyl 2,2-dimethyl-5-((6-((2'-(trifluoromethyl)biphenyl-4-yl)methoxy)-3,4-dihydroisoquinolin-2(1H)-yl)methyl)-1,3-dioxan-5-ylcarbamate

반응식

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([CH2:12][C:13]1([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])[CH2:18][O:17][C:16]([CH3:20])([CH3:19])[O:15][CH2:14]1)[CH2:6][CH2:5]2.Cl[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=2[C:43]([F:46])([F:45])[F:44])=[CH:33][CH:32]=1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C>[CH3:19][C:16]1([CH3:20])[O:17][CH2:18][C:13]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])([CH2:12][N:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:30][C:31]4[CH:32]=[CH:33][C:34]([C:37]5[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=5[C:43]([F:44])([F:45])[F:46])=[CH:35][CH:36]=4)[CH:3]=3)[CH2:8]2)[CH2:14][O:15]1