3-Chloro-4-isopropoxybenzaldehyde → 3-Chloro-4-(propan-2-yloxy)benzoic acid

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH:11]([CH3:13])[CH3:12])[CH:5]=[O:6].ClC1C=C(C=CC=1OCC)C=[O:19]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH:11]([CH3:13])[CH3:12])[C:5]([OH:19])=[O:6]

참가 물질

반응물 2

HCID 43398893-Chloro-4-isopropoxybenzaldehyde

HCID 47700353-Chloro-4-ethoxybenzaldehyde

생성물 1

HCID 225977283-Chloro-4-(propan-2-yloxy)benzoic acid수율 98%

실험 절차

When the 3-chloro-4-isopropoxybenzaldehyde was substituted for 3-chloro-4-ethoxybenzaldehyde in Example 49, Step A the identical process afforded the title compound in 98% yield, as a colourless solid. 1H-NMR (CDCl3) 1.4 (d, 6H, J=5.1 Hz); 4.67 (m, 1H); 6.95 (m, 1H); 7.96 (m, 1H); 8.10 (m, 1H).

출처 및 근거

ORD 기록: ord-b0058cda07e94abfa0f83bf66ffc69d5
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09181182B2

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