3-Chloro-4-ethoxybenzaldehyde → 3-Chloro-4-(pentyloxy)benzoic acid

HRID 710429

반응식

HRID 710429 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH:5]=[O:6].ClC1C=C(C=CC=1OCC)C=[O:21]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:5]([OH:21])=[O:6]

참가 물질

3

반응물 2

HCID 47700353-Chloro-4-ethoxybenzaldehydeHCID 547952073-Chloro-4-(pentyloxy)benzaldehyde

생성물 1

HCID 613791933-Chloro-4-(pentyloxy)benzoic acid수율 72%

실험 절차

When the product of Step A was substituted for 3-chloro-4-ethoxybenzaldehyde in Example 49, Step A the identical process afforded the title compound in 72% yield. 1H-NMR (CDCl3) 0.92 (tr, 3H); 1.42-1.65 (m, 4H); 1.76-1.9 (m, 2H); 4.08 (tr, 2H, J=6.51 Hz); 6.92 (d, 1H, J=8.7 Hz); 7.95 (dd, 1H, J=2.1, 8.61 Hz); 8.1 (d, 1H, J=2.07 Hz).

출처 및 근거

ORD 기록
ord-d871737a95014a91a973efbae3b28b10
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181182B2

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